SAB4500900
Anti-LMTK2 antibody produced in rabbit
affinity isolated antibody
别名:
Apoptosis-associated tyrosine kinase 2, Brain-enriched kinase, Kinase/phosphatase/inhibitor 2, Lemur tyrosine kinase 2, Serine/threonine protein kinase KPI-2
产品名称
Anti-LMTK2 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 164 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LMTK2(22853)
Application
Anti-LMTK2 antibody has been used in western blotting.
Biochem/physiol Actions
Lemur tyrosine kinase 2 (LMTK2) participates in endosomal membrane trafficking and neuronal physiology. It also participates in the differentiation of tissues and acts as a negative regulator of nerve growth factor (NGF)-induced neuronal differentiation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-LMTK2 antibody detects endogenous levels of total LMTK2 protein.
Lemur tyrosine kinase 2 (LMTK2) is a serine/threonine kinase, located in endosomal compartments. It is also termed as BREK (brain-enriched kinase), AATYK-2 (apoptosis-associated tyrosine kinase 2), cdk5, KPI-2 and Cprk. It is expressed at high levels in the plasma membrane. LMTK2 consists of 1503 amino acids and is located on human chromosome 7q21.
Immunogen
The antiserum was produced against synthesized peptide derived from human LMTK2.
Immunogen Range: 651-700
Immunogen Range: 651-700
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Determination of the membrane topology of lemur tyrosine kinase 2 (LMTK2) by fluorescence protease protection
Nixon A, et al.
American Journal of Physiology. Cell Physiology, 304(2), C164-C164 (2013)
Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers?
Wiklund F
Genome Medicine, 2(7), 45-45 (2010)
Daniel F Cruz et al.
Frontiers in oncology, 11, 596861-596861 (2021-04-06)
Lemur tyrosine kinase 2 (LMTK2) is a transmembrane Ser/Thr kinase whose role has been increasingly recognized; however, when compared to other kinases, understanding of the LMTK2 networks and biological functions is still limited. Recent data have shown that transforming growth
Signal dependent ER export of lemur tyrosine kinase 2
Butler EC and Bradbury NA
BMC Cell Biology, 16(1), 26-26 (2015)
Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members
Conti A, et al.
Cancer Letters, 389, 59-69 (2017)
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