SAB4500961
Anti-FLT3 antibody produced in rabbit
affinity isolated antibody
别名:
CD135 antigen, STK-1, Stem cell tyrosine kinase 1, Tyrosine-protein kinase receptor FLT3
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
western blot
western blot
Species reactivity:
mouse, human
Citations:
3
Technique(s):
ELISA: 1:1000
western blot: 1:500-1:1000
western blot: 1:500-1:1000
Uniprot accession no.:
产品名称
Anti-FLT3 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 112 kDa
species reactivity
mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FLT3(2322)
Biochem/physiol Actions
Mutation in FLT3 (Fms-like tyrosine kinase) results in acute myeloid leukemia and it also induces warburg effect and offers therapeutic sensitivity to glycolytic inhibition.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Anti-FLT3 antibody detects endogenous levels of total FLT3 protein.
FLT3 (Fms-like tyrosine kinase) is a member of tyrosine kinase (RTK) family. It has an extracellular domain consisting of five immunoglobulin-like domains and an intracellular kinase domain interrupted by a kinase insert. It is located on human chromosome 13q12.
Immunogen
The antiserum was produced against synthesized peptide derived from human FLT3.
Immunogen Range: 565-614
Immunogen Range: 565-614
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255
Tracy S, et al.
Cancer Research, 64(20), 7241-7244 (2004)
Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD
Kazi JU, et al.
Cellular and Molecular Life Sciences, 74(14), 2679-2688 (2017)
ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition
Ju HQ, et al.
Leukemia, 31(10), 2143-2143 (2017)
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