产品名称
抗-MTOR 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 2888 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MTOR(2475)
Application
抗-MTOR，C 端抗体已用于蛋白质印迹。
Biochem/physiol Actions
雷帕霉素的机械/哺乳动物靶标（mTOR）控制蛋白质翻译、细胞生长、生存、侵袭和代谢。 它起细胞内信号调节剂的作用，将细胞外事件与细胞内过程联系起来。mTOR 还作用于蛋白质合成机制。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
您可完全放心地评估我们的抗体。如果抗体在您的应用中未发挥预期作用，可全额抵扣货款或更换抗体。 了解更多。
General description
哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin, mTOR)或雷帕霉素作用靶点(mechanistic target of rapamycin)是一种丝氨酸/苏氨酸激酶。它是磷酸肌醇3激酶（PI 3激酶或PI3K）家族成员。定位于人类染色体1p36.22上。
抗-MTOR 抗体可检测内源性总 MTOR 蛋白水平。
Immunogen
针对人源 mTOR 的合成肽产生抗血清。
免疫原范围：2447-2496
免疫原范围：2447-2496
Physical form
兔IgG，溶于磷酸盐缓冲盐水（不含Mg2+和Ca2+），pH7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Lexing Li et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(4), 1723-1734 (2018-08-06)
Autophagy is a process of evolutionarily conservative degradation, which could maintain cellular homeostasis and cope with various types of stress. LncRNAs are considered as competing endogenous RNAs (ceRNAs) contributing to autophagy. GAS5 has been suggested as a new potential factor
Fengling Song et al.
Journal of cellular physiology, 234(5), 7420-7434 (2018-10-27)
Long noncoding RNA urothelial carcinoma associated 1 (UCA1) has been implicated in the growth and metastasis of colorectal cancer (CRC), and autophagy contributes to tumorigenesis and cancer cell survival. However, the regulatory role of UCA1 in CRC cell viability by
Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition
Marques-Ramos A, et al.
RNA (2017)
The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma
Miyahara H, et al.
Cancer Letters, 400, 110-116 (2017)
Expression of the mTOR pathway regulators in human pituitary adenomas indicates the clinical course
Jia W, et al.
Anticancer Research, 33(8), 3123-3131 (2013)
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