SAB4501145
Anti-LATS1 antibody produced in rabbit
affinity isolated antibody
别名:
Kinase phosphorylated during mitosis protein, Large tumor suppressor homolog 1, Serine/threonine-protein kinase kpm, WARTS protein kinase, h-warts/ Large tumor suppressor homolog 2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 126 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000, immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LATS1(9113)
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General description
Anti-LATS1 Antibody detects endogenous levels of total LATS1 protein.
The LATS1 (large tumor suppressor kinase 1) gene encodes a serine/threonine kinase and is located on human chromosome 6q24-25. It is present in the mitotic apparatus. It is also called as WARTS.
Immunogen
The antiserum was produced against synthesized peptide derived from human LATS1/2.
Immunogen Range: 1041-1090
Immunogen Range: 1041-1090
Biochem/physiol Actions
The LATS1 (large tumor suppressor kinase 1) protein repress the multiplication and invasion of cervical cancer. It acts as a cell cycle inhibitor. Low level expression of LATS1 is associated with the progression and prognosis of glioma. It is a tumor suppressor gene, thereby it participates in various mitotic processes.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
LATS1 suppresses proliferation and invasion of cervical cancer
Deng J, et al.
Molecular Medicine Reports, 15(4), 1654-1660 (2017)
Decreased expression of LATS1 is correlated with the progression and prognosis of glioma
Ji T, et al.
Journal of Experimental & Clinical Cancer Research (2012)
Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation
Wierzbicki PM, et al.
World Journal of Gastroenterology, 19(27), 4363-4373 (2013)
Di Li et al.
CNS neuroscience & therapeutics, 24(10), 906-916 (2018-03-01)
To investigate the roles of Lats1/p-YAP1 pathway in TBI-induced neuronal apoptosis and neurological deficits in rats. We found that Lats1 and YAP1 were expressed in cerebral cortex neurons of Sprague-Dawley rats, and the phosphorylation levels of Lats1 and YAP1 in
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