SAB4501464
Anti-HSP60 antibody produced in rabbit
affinity isolated antibody
别名:
60 kDa chaperonin, CH60, CPN60, HSP-60, Heat shock protein 60
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC, WB
Citations:
11
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 61 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HSPD1(3329)
General description
Hsp60 (heat shock protein family D member 1) is a mitochondrial chaperone, located in the endoplasmic reticulum (ER). It is mapped to human chromosome 2q33.1.
Anti-HSP60 antibody detects endogenous levels of total HSP60 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human HSP60.
Immunogen Range: 511-560
Immunogen Range: 511-560
Application
Anti-HSP60, C-Terminal antibody has been used in SDS/PAGE and western blot analysis.
Biochem/physiol Actions
Hsp60 (heat shock protein family D member 1) helps to gather proteins that are imported into mitochondrial matrix. Overexpression of Hsp60 results in Behcet′s Disease (BD),Crohn′s disease, juvenile dermatomyositis (JDM), and juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis
Arya RK, et al.
Scientific Reports (2015)
OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation
Barrera M, et al.
Febs Letters, 590(19), 3309-3322 (2016)
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy.
Dan A Tudorica et al.
The Journal of cell biology, 223(7) (2024-05-10)
Activation of PINK1 and Parkin in response to mitochondrial damage initiates a response that includes phosphorylation of RAB7A at Ser72. Rubicon is a RAB7A binding negative regulator of autophagy. The structure of the Rubicon:RAB7A complex suggests that phosphorylation of RAB7A
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4501464-100UG | 04061837744655 |