产品名称
Anti-Keratin 8 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 53 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KRT8(3856)
Application
Anti-Keratin 8, C-Terminal antibody has been used in immunofluorescence.
Biochem/physiol Actions
Keratins act as cytoprotective proteins. KRT8 plays an important role in the pathophysiology of RPE (retinal pigment epithelium). It plays a hepatoprotective role against mechanical and toxic injury.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Keratin 8 (KRT8) is an intermediate filaments protein, that is located on human chromosome 12q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human Keratin 8.
Immunogen Range: 401-450
Immunogen Range: 401-450
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Keratin 8 Y54H and G62C mutations are not associated with liver disease
Halangk J, et al.
Journal of medical Genetics (2004)
Loss of c-KIT expression in thyroid cancer cells
Franceschi S, et al.
PLoS ONE (2017)
WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation
Xu M, et al.
Nature Communications (2017)
Marie Alexandra Albaret et al.
Cancers, 10(11) (2018-11-21)
Accumulating evidence supports the remarkable presence at the membrane surface of cancer cells of proteins, which are normally expressed in the intracellular compartment. Although these proteins, referred to as externalized proteins, represent a highly promising source of accessible and druggable
Alan T Tang et al.
PLoS biology, 21(2), e3001989-e3001989 (2023-02-07)
Angiotensin-converting enzyme 2 (ACE2) is the cell-surface receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). While its central role in Coronavirus Disease 2019 (COVID-19) pathogenesis is indisputable, there remains significant debate regarding the role of this transmembrane carboxypeptidase in
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