产品名称
Anti-HSL antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 116 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LIPE(3991)
Application
Anti-HSL antibody has been used in SDS-PAGE and western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Hormone sensitive lipase (HSL) plays an important role in lipolysis. Lack of HSL results in histologic abnormalities in white adipose tissue and an increase in macrophage infiltration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-HSL Antibody detects endogenous levels of total HSL protein.
Hormone sensitive lipase (HSL) is coded by LIPE (lipase E) gene. It is an intracellular lipase which acts on triglycerides, diglycerides, monoglycerides, cholesterol esters and retinyl esters. It is mapped to human chromosome 19q13.
Hormone sensitive lipase (HSL) is coded by LIPE (lipase E) gene. It is an intracellular lipase which acts on triglycerides, diglycerides, monoglycerides, cholesterol esters and retinyl esters. It is mapped to human chromosome 19q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human HSL.
Immunogen Range: 518-567
Immunogen Range: 518-567
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Polysaccharide-Enriched Fraction from Amillariella Mellea Fruiting Body Improves Insulin Resistance.
Siwen Yang et al.
Molecules (Basel, Switzerland), 24(1) (2018-12-26)
Despite the edible fungus Amillariella mellea possessing a variety of biological activities, its effects on diabetes are still unclear. Polysaccharides are the main bioactive ingredients. In order to destroy the cell wall to obtain more polysaccharides, we used NaOH solution
Upregulation of Pnpla2 and Abhd5 and downregulation of G0s2 gene expression in mesenteric white adipose tissue as a potential reason for elevated concentration of circulating NEFA after removal of retroperitoneal, epididymal, and inguinal adipose tissue.
Dettlaff-Pokora A, et al.
Molecular and Cellular Biochemistry, 422(1-2), 21-29 (2016)
Progesterone-induced down-regulation of hormone sensitive lipase (Lipe) and up-regulation of G0/G1 switch 2 (G0s2) genes expression in inguinal adipose tissue of female rats is reflected by diminished rate of lipolysis
Stelmanska E, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 147, 31-39 (2015)
Identification of microdeletions spanning the Diamond-Blackfan anemia locus on 19q13 and evidence for genetic heterogeneity
Gustavsson P, et al.
American Journal of Human Genetics, 63(5), 1388-1395 (1998)
Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes
Albert JS, et al.
The New England Journal of Medicine, 370(24), 2307-2315 (2014)
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