SAB4501885
Anti-MLK3 antibody produced in rabbit
affinity isolated antibody
别名:
M3K11, MAP3K11, MAPKKK11, kinase MLK3, mitogen activated protein kinase kinase kinase 11
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 92 kDa
种属反应性
human, rat, mouse
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MAP3K11(4296)
一般描述
Anti-MLK3 Antibody detects endogenous levels of total MLK3 protein.
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11) or mixed lineage kinase 3 (MLK3) possesses an amino-terminal Src-homology-3 (SH3) domain followed by a kinase domain, a leucine-zipper region, a Cdc42/RAC interacting motif (CRIB) and a carboxy terminal proline/serine/threonine-rich domain. The gene encoding this serine/threonine protein kinase is localized on human chromosome 11q13.1.
免疫原
The antiserum was produced against synthesized peptide derived from human MLK3.
Immunogen Range: 640-689
Immunogen Range: 640-689
生化/生理作用
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11), also known as mixed lineage kinase 3 (MLK3), phosphorylates c-Jun N-terminal kinases. It acts as a modulator of the mitogen-activated protein kinase (MAPK) pathway. The protein is associated with various cancers.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation.
Velho S, et al.
BMC Cancer, 14(1), 182-182 (2014)
Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis.
Amako Y, et al.
The Journal of Biological Chemistry, 288(34), 24753-24763 (2013)
MLK3 is part of a feedback mechanism that regulates different cellular responses to reactive oxygen species.
Lee HS, et al.
Science Signaling, 7(328), ra52-ra52 (2014)
Wayne Bowden et al.
Molecular human reproduction, 15(9), 563-568 (2009-07-02)
Uterine leiomyomas (ULs) are benign monoclonal tumors originating from myometrial tissue in the uterus. Genetic pathways that lead to myometrial transformation into leiomyomas are largely unknown. Approximately 40% of ULs are karyotypically abnormal by G-banding; however, the remaining 60% of
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