Anti-HNRNP M antibody produced in rabbit

Anti-HNRNP M Antibody detects endogenous levels of total HNRNP M protein.

HNRNP M (heterogeneous nuclear ribonucleoprotein M) gene is mapped to human chromosome 19p13.2. It codes for a nucleocytoplasmic shuttling RNA binding protein.

The antiserum was produced against synthesized peptide derived from human hnRNP M.

Immunogen Range: 11-60

HnRNP M (heterogeneous nuclear ribonucleoprotein M) is an RNA binding protein and participates in mRNA splicing mechanism. It is significantly involved in the formation of mature mRNAs from heterogeneous nuclear RNAs. The encoded protein acts as an important gene expression regulating factor. HnRNPM is involved in the activation of IRES (internal ribosomal entry site)-dependent translation of FGF1 (fibroblast growth factor 1). Thus, this protein is associated with myoblast differentiation. HNRNP M expression is associated with the invasion and metastasis events of tumor cells. Upregulation of HNRNP M is observed in breast cancer and human colorectal epithelial carcinogenesis. Therefore, HnRNP M may serve as an important biomarker for cancer.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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