SAB4501977
Anti-NF1 antibody produced in rabbit
affinity isolated antibody
别名:
Neurofibromatosis-related protein NF-1, Neurofibromin
产品名称
Anti-NF1 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 319 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NF1(4763)
Biochem/physiol Actions
NF1 (neurofibromin 1) is a tumor suppressor gene and negatively regulates RAS (proto-oncogene, GTPase). Mutation in NF1 is strongly associated with the pathogenesis of melanoma and also causes neurofibromatosis type 1. Loss of NF1 allele results in benign neurofibromas in nonmyelinating Schwann cell and is associated with desmoplastic melanoma.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-NF1 Antibody detects endogenous levels of total NF1 protein.
NF1 (neurofibromin 1) gene is mapped to human chromosome 17q11.2. The protein encoded contains more than 2800 amino acids.
Immunogen
The antiserum was produced against synthesized peptide derived from human NF1.
Immunogen Range: 1551-1600
Immunogen Range: 1551-1600
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Updated nomenclature for human and mouse neurofibromatosis type 1 genes.
Corina Anastasaki et al.
Neurology. Genetics, 3(4), e169-e169 (2017-08-15)
Helena Cirenajwis et al.
Molecular oncology, 11(4), 438-451 (2017-03-08)
In general, melanoma can be considered as a UV-driven disease with an aggressive metastatic course and high mutational load, with only few tumors (acral, mucosal, and uveal melanomas) not induced by sunlight and possessing a lower mutational load. The most
D H Ki et al.
Oncogene, 36(8), 1058-1068 (2016-08-02)
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, frequently metastatic sarcomas that are associated with neurofibromatosis type 1 (NF1), a prominent inherited genetic disease in humans. Although loss of the NF1 gene predisposes to MPNST induction, relatively long tumor latency
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