Anti-NOTCH4 (Cleaved-Val¹⁴³²), C-Terminal antibody produced in rabbit

Anti-NOTCH4 (Cleaved-Val¹⁴³²) antibody detects endogenous levels of fragment of activated NOTCH4 (Cleaved-Val¹⁴³²) protein.

The NOTCH4 gene is mapped to human chromosome 6p21.32.

The antiserum was produced against synthesized peptide derived from human NOTCH4.

Immunogen Range: 1401-1450

The NOTCH4 gene is associated with the process of angiogenesis and homeostasis during developmental process. NOTCH4 plays a role in Notch signaling pathway which mediates epithelial cell and stem cell homeostasis. Notch signaling pathway is induced in a number of cancer types including colon, breast, pancreatic, cervical, head and neck, renal carcinoma, prostate cancer, Large-cell and Hodgkin lymphomas.Thus, NOTCH4 is known to participate in tumorigenesis. This gene is involved in the development of central nervous system and controls neuronal maturation. Mutations in the gene might be associated with schizophrenia.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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