SAB4502050
Anti-OR1D2 antibody produced in rabbit
affinity isolated antibody
别名:
OR17-4, Olfactory receptor 17-4, Olfactory receptor 1D2, Olfactory receptor OR17-6, Olfactory receptor-like protein HGMP07E
产品名称
Anti-OR1D2 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 35 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... OR1D2(4991)
General description
Anti-OR1D2 antibody detects endogenous levels of total OR1D2 protein.
The OR1D2 (olfactory receptor family 1 subfamily D member 2) gene is located on human chromosome 17p13.3. The gene is considered as the first olfactory receptor expressed in the nose. It is also found to be expressed in spermatozoa. The encoded protein is a member of G protein-coupled receptor superfamily and exists as a homo-oligomer.
Biochem/physiol Actions
The protein encoded by OR1D2 (olfactory receptor family 1 subfamily D member 2) gene takes part in the process of fertilization by mediating the communication between the sperm and egg via chemotaxis. Sperm expressing OR1D2 is known to migrate toward odorant ligands such as lilial, floralozone and bourgeonal.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Immunogen
The antiserum was produced against synthesized peptide derived from human OR1D2.
Immunogen Range: 201-250
Immunogen Range: 201-250
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
A partial deletion of the aspartoacylase gene is the cause of Canavan disease in a family from Mexico.
F E Tahmaz et al.
Journal of medical genetics, 38(3), E9-E9 (2001-03-10)
G Ottaviano et al.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 270(12), 3079-3086 (2013-03-26)
Olfactory receptor (OR) expression is also present in the sperm cells and could mediate sperm chemotaxis. OR1D2 was the first OR expressed in the testis demonstrated to be involved in chemotaxis and to be expressed also in the nose with
Marc Spehr et al.
Science (New York, N.Y.), 299(5615), 2054-2058 (2003-03-29)
Although it has been known for some time that olfactory receptors (ORs) reside in spermatozoa, the function of these ORs is unknown. Here, we identified, cloned, and functionally expressed a previously undescribed human testicular OR, hOR17-4. With the use of
Fallou Wade et al.
The Journal of biological chemistry, 286(17), 15252-15259 (2011-04-02)
G-protein-coupled receptor homo-oligomerization has been increasingly reported. However, little is known regarding the relationship between activation of the receptor and its association/conformational states. The mammalian olfactory receptors (ORs) belong to the G protein-coupled receptor superfamily. In this study, the homo-oligomerization
Brian L Cook et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(29), 11925-11930 (2009-07-08)
Although understanding of the olfactory system has progressed at the level of downstream receptor signaling and the wiring of olfactory neurons, the system remains poorly understood at the molecular level of the receptors and their interaction with and recognition of
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