SAB4502149
Anti-PDGF Receptor β antibody produced in rabbit
affinity isolated antibody
别名:
CD140b, PDGF-R-β, PDGFR, PDGFR-β, kinase PDGFR-β
产品名称
Anti-PDGF Receptor β antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 123 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PDGFRB(5159)
Biochem/physiol Actions
PDGFRB (platelet-derived growth factor β) has its key role in cell proliferation, differentiation and survival. It also mediates cell movement and tissue repair mechanism. PDGFβ functions as a mitogen, by binding to the PDGF receptor β. Variation in PDGFRB gene leads to a number of cancer types including glioblastoma, dermatofibrosarcoma, medulloblastoma and endocrine pancreatic tumor. PDGFR-β signaling pathway, can thus serve as an important target for cancer therapy.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
The PDGFRB (platelet-derived growth factor receptor β) gene is mapped to human chromosome 5q32. The encoded protein is a cell surface tyrosine kinase receptor. Anti-PDGF receptor β antibody detects endogenous levels of total PDGF receptor β protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human PDGF Receptor beta.
Immunogen Range: 718-767
Immunogen Range: 718-767
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Tyrosines-740/751 of PDGFRbeta contribute to the activation of Akt/Hif1alphaTGFbeta nexus to drive high glucose-induced glomerular mesangial cell hypertrophy
Das F, et al.
Cellular Signalling, 42(6), 44-53 (2018)
The 3?-end region of the human PDGFR-beta core promoter nuclease hypersensitive element forms a mixture of two unique end-insertion G-quadruplexes
Onel B, et al.
Biochim. Biophys. Acta Gen. Subj., 1862(4), 846-854 (2018)
Nigella sativa L. seed extracts promote wound healing progress by activating VEGF and PDGF signaling pathways: An in vitro and in silico study.
Palanisamy, et al.
F1000Research, 12, 436-436 (2023)
Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis.
Martignetti J A, et al.
American Journal of Human Genetics, 92(6), 1001-1007 (2013)
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