产品名称
抗-PI3-激酶 p85-α 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 83 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PIK3R1(5295)
相关类别
Application
兔抗PI3-激酶p85-α抗体可用于蛋白质印迹。
Biochem/physiol Actions
PIK3R1 (磷酸肌醇-3-激酶调节亚基1) 已知可介导免疫细胞分化、发育和功能。PIK3R1的显性突变导致PI3K信号通路超活化,引起免疫缺陷和SHORT综合征(身材矮小、关节伸展过度、疝气、眼凹陷、Rieger异常和龋齿)。 PI3K 是胰岛素和生长因子信号传导的重要组成部分。一般认为PIK3R1 基因不能耐受人体功能的变化。在人体中,PIK3R1的下调见于多种癌症。PIK3R1被认为是一种肿瘤抑制基因。PIK3R1介导肿瘤发生和恶性进展(malignant progression)。该基因保护受体酪氨酸激酶活性并参与IA 类PI3K 的活化。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果,我们将给予您完全的赔偿或更换抗体。 了解更多。
General description
PIK3R1(磷酸肌醇-3-激酶调节亚基1)基因位于人类染色体5q13.1。它可编码p85α调节亚基。
抗-PI3-激酶p85-α抗体可检测内源性总PI3-激酶p85-α蛋白的水平。
Immunogen
该抗血清是针对人PI3-激酶p85-α/γ合成肽制备的。
免疫原范围:436-485
免疫原范围:436-485
Physical form
兔IgG,溶于磷酸盐缓冲盐水(不含Mg2+和Ca2+),pH7.4,150mM NaCl,0.02%叠氮化钠和50%甘油中。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
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Yang Y
Nature Communications, 6:7369 (2015)
Oncogenic mutations in GNAQ occur early in uveal melanoma.
Onken MD
Investigative Ophthalmology & Visual Science, 49(12), 5230-5234 (2008)
Qiong Wu et al.
Cell death & disease, 9(2), 232-232 (2018-02-16)
G-protein-coupled receptor (GPCR)-related proteins are dysregulated and the GPCR CC-chemokine receptor 10 (CCR10) is significantly upregulated in inflammation-driven HCC. However, CCR10's role in inflammation-driven hepatocarcinogenesis remains unknown. The aim of this study was to evaluate the role of CCR10 in
Aberrant low expression of p85? in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b.
Chen Y
Oncogene, 36(33), 4692-4705 (2017)
Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase.
Solheim MH
Investigative Ophthalmology & Visual Science, 58(7), 3100-3106 (2017)
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