SAB4502260
Anti-PPAR-α antibody produced in rabbit
affinity isolated antibody
别名:
NR1C1, PPAR-α, PPARA Peroxisome proliferator-activated receptor α
产品名称
Anti-PPAR-α antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 52 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PPARA(5465)
Biochem/physiol Actions
PPAR-α (peroxisome proliferator-activated receptor α) is a receptor transcription factor that inhibits inflammation, by preventing the nuclear factor κB activation. Omega-3 long-chain polyunsaturated fatty acids is known to be the ligand that brings out the anti-inflammatory action of Ppar-α. Ppar-α is involved in epidermal proliferation and differentiation and therefore serves as a skin barrier. PPARα mediates lipid metabolism by inducing fatty acid oxidation and also regulates glucose metabolism. Variation in the gene is observed in schizophrenia.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-PPAR-α antibody detects endogenous levels of total PPAR-α protein.
The PPAR-α (peroxisome proliferator-activated receptor α) gene is mapped to human chromosome 22q13.31. Ppar-α is localized to the nucleus.
Immunogen
The antiserum was produced against synthesized peptide derived from human PPAR-alpha.
Immunogen Range: 6-55
Immunogen Range: 6-55
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Microdeletions involving chromosomes 12 and 22 associated with syndromic Duane retraction syndrome.
Abu-Amero KK
Ophthalmic Genetics, 35(3), 162-169 (2014)
Role of PPAR? in the attenuation of bile acid-induced apoptosis by omega-3 long-chain polyunsaturated fatty acids in cultured hepatocytes.
Tillman EM
Pediatric Research, 79(5), 754-758 (2016)
Eupatilin with PPAR? agonistic effects inhibits TNF?-induced MMP signaling in HaCaT cells.
Jung Y
Biochemical and Biophysical Research Communications, 493(1), 220-226 (2017)
Nutrient-sensing nuclear receptors PPAR? and FXR control liver energy balance.
Preidis GA
The Journal of Clinical Investigation, 127(4), 1193-1201 (2017)
An association between the PPAR?-L162V polymorphism and nicotine dependency among patients with schizophrenia.
Nadalin S
Comprehensive Psychiatry, 70, 118-124 (2016)
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