生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 41 kDa
种属反应性
human, mouse, rat
浓度
~1 mg/mL
技术
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NDRG3(57446)
一般描述
NDRG3 (N-myc downstream-regulated gene 3 protein) is a novel member of N-myc down-regulated gene (NDRG) family mapped to human chromosomal location 20q11.21-q11.23. It is abundantly expressed in brain, prostate, ovary, and testis tissues. It is localized to the outer layers of seminiferous epithelium.
免疫原
The antiserum was produced against synthesized peptide derived from human NDRG3.
Immunogen Range: 206-255
Immunogen Range: 206-255
应用
Anti-NDRG3 antibody produced in rabbit is suitable for immunohistochemistry and western blot.
生化/生理作用
N-myc downstream-regulated gene 3 protein (NDRG3) is involved in prostate cancer cell growth in vitro and in vivo. It acts as an androgen regulated and prostate enriched gene during controlling of cancer cell growth. Thus, overexpression of NDRG3 has been linked to the malignant phenotype of tumors. In hepatitis B virus (HBV)-related hepatocellular carcinoma cell line, NDRG3 gene is inversely expressed with the miR-122 expression. Thus, it has been reported that in conjugation with miR-122, NDRG3 can be a potential therapeutic marker for hepatocellular carcinoma (HCC). Prominent localization of NDRG3 in the epithelium cells indicate its role in spermatogenesis. It also plays an important role in lactate-induced hypoxia signaling pathway in hypoxia. Its protein level expression in cell is negatively regulated by oxygen, whereas, whereas excess lactate produced under prolonged hypoxia blocks its proteasomal degradation by binding to NDRG3.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
W Zhao et al.
Biochimica et biophysica acta, 1519(1-2), 134-138 (2001-06-19)
We report the cloning and expression pattern of a novel N-myc downstream-regulated gene 3 (NDRG3), located on human chromosome 20q11.21-11.23. The NDRG3 cDNA is 2588 base pair in length, encoding a 363 amino acid polypeptide highly related to mouse Ndr3
Xianghu Qu et al.
Molecular and cellular biochemistry, 229(1-2), 35-44 (2002-04-09)
NDRG1 (N-Myc downstream regulated) is upregulated during cell differentiation, repressed by N-myc and c-myc in embryonic cells, and suppressed in several tumor cells. A nonsense mutation in the NDRG1 gene has been reported to be causative for hereditary motor and
Weiqun Wang et al.
International journal of cancer, 124(3), 521-530 (2008-11-01)
NDRG3 belongs to the N-myc down-regulated gene (NDRG) family that contains 4 paralogs: NDRG1, -2, -3 and -4. The function of NDRG3 and its relationship to cancer has not been studied. We herein report our examination of the expression and
Kyung Chan Park et al.
BMB reports, 48(6), 301-302 (2015-05-06)
Hypoxia is associated with many pathological conditions as well as the normal physiology of metazoans. We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). Oxygen negatively regulates NDRG3 expression
Chun-Guang Fan et al.
Oncology reports, 26(5), 1281-1286 (2011-07-05)
microRNAs (miRNAs) are short, non-coding RNAs with post-transcriptional regulatory functions that participate in diverse biological pathways. miR-122, a liver-specific miRNA, has been found to be down-regulated in hepatocellular carcinoma (HCC) and HCC-derived cell lines. In this study, miR-122 was down-regulated
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