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SAB4502573

Anti-C-RAF antibody

Name: Anti-C-RAF antibody
Brand: SIGMA

rabbit polyclonal

别名:

C-RAF, C-Raf, CRAF, Protein kinase raf 1, kinase Raf1

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA, IHC, WB

Citations:

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属性

产品名称

Anti-C-RAF antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 73 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

NCBI accession no.

P04049

UniProt accession no.

P04049

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RAF1(5894)

说明

General description

Anti-C-RAF Antibody detects endogenous levels of total C-RAF protein.
Raf-1 proto-oncogene, serine/threonine kinase (RAF1) or C-RAF is an anti-apoptotic protein. The gene encoding it is localized on human chromosome 3p25.2.

Immunogen

The antiserum was produced against synthesized peptide derived from human C-RAF.

Immunogen Range: 271-320

Biochem/physiol Actions

Raf-1 proto-oncogene, serine/threonine kinase (RAF1) or C-RAF is a crucial component of the Raf/mitogen-activated extracellular signal-regulated kinase (MEK)/extracellular regulated protein kinase (ERK) signaling cascade. It functions as an activator of MEK-1 and -2. The protein is upregulated in many cancers. Mutations in the gene encoding RAF1 have been linked to Noonan syndrome.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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存储类别

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

低风险生物材料

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

210634

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Neonatal pulmonary arterial hypertension and Noonan syndrome: two fatal cases with a specific RAF1 mutation.

Hopper RK

American Journal of Medical Genetics (2015)

EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells

Breast Cancer Research (2011)

The lack of Raf-1 kinase feedback regulation enhances antiapoptosis in cancer cells.

Ma SQ

Oncogene (2017)

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全球贸易项目编号

货号	GTIN
SAB4502573-100UG	04061835717118