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安全信息

SAB4502615

Sigma-Aldrich

Anti-NF-κB p65 antibody produced in rabbit

affinity isolated antibody

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别名:
NFKB3, RELA, TF65, nuclear factor NF-κ-B p65 subunit, p65
MDL编号:
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

antigen 60 kDa

种属反应性

human, rat, mouse

浓度

~1 mg/mL

技术

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... RELA(5970)

一般描述

Anti-NF-κB p65 Antibody detects endogenous levels of total NF-κB p65 protein.
RELA (v-rel avian reticuloendotheliosis viral oncogene homolog A), also known as nuclear factor κ-B (NF-κ-B) p65 subunit, codes for an important constituent of the NF-κB complex. The gene encoding it is localized on human chromosome 11q13.1. It is also referred as nuclear factor κB subunit 3 (NFκB3).

免疫原

The antiserum was produced against synthesized peptide derived from human NF-kappaB p65.

Immunogen Range: 247-296

应用

Anti-NF-κB p65 antibody produced in rabbit is used in Western Blotting.

生化/生理作用

RELA (v-rel avian reticuloendotheliosis viral oncogene homolog A) or nuclear factor NF-κ-B p65 subunit participates in the nuclear factor κ-B (NFκB) signaling pathway. It also modulates inflammation. Alterations in the gene have been linked to schizophrenia and startle reactions.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Bone morphogenetic protein-2 exhibits therapeutic benefits for osteonecrosis of the femoral head through induction of cartilage and bone cells.
Wang C, et al.
Experimental and Therapeutic Medicine (2018)
Reversal of cardiac and skeletal manifestations of Duchenne muscular dystrophy by cardiosphere-derived cells and their exosomes in mdx dystrophic mice and in human Duchenne cardiomyocytes.
Aminzadeh MA, et al.
bioRxiv, 128900-128900 (2017)
Siwei Tan et al.
Cell death & disease, 12(5), 474-474 (2021-05-14)
Fas/Fas ligand (FasL)-mediated cell apoptosis involves a variety of physiological and pathological processes including chronic hepatic diseases, and hepatocytes apoptosis contributes to the development of liver fibrosis following various causes. However, the mechanism of the Fas/FasL signaling and hepatocytes apoptosis
Variants of the RELA gene are associated with schizophrenia and their startle responses.
Hashimoto R, et al.
Neuropsychopharmacology, 36(9), 1921-1921 (2011)
Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.
Pare G, et al.
PLoS Genetics, 7(4), e1001374-e1001374 (2011)

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