SAB4502626
Anti-DNA Polymerase ζ, N-Terminal antibody produced in rabbit
affinity isolated antibody
别名:
DNA polymerase ζ catalytic subunit, DPOLZ, DPOZ, POLZ, REV3L
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunohistochemistry
immunohistochemistry
Species reactivity:
mouse, human
Citations:
4
Technique(s):
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
immunohistochemistry: 1:50-1:100
Uniprot accession no.:
产品名称
Anti-DNA Polymerase ζ, N-Terminal antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 352 kDa
species reactivity
mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... REV3L(5980)
Biochem/physiol Actions
REV3L (reversionless 3-like) is predominantly involved in DNA damage response, induced by ultraviolet radiation and chemical damaging agents such as cisplatin. The encoded protein DNA Polymerase ζ catalyzes the translesion synthesis (TLS) with less stringent and lower processivity. Loss of gene function is embryonically lethal. Upregulation of REV3L results in spontaneous mutations.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Anti-DNA Polymerase ζ antibody detects endogenous levels of total DNA polymerase ζ protein.
The REV3L (reversionless 3-like) gene is mapped to human chromosome 6q21. It codes for a ~350 kDa protein DNA polymerase ζ which localizes to mitochondria.
Immunogen
The antiserum was produced against synthesized peptide derived from human DNA Polymerase zeta.
Immunogen Range: 231-280
Immunogen Range: 231-280
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
REV3L, the catalytic subunit of DNA polymerase ?, is involved in the progression and chemoresistance of esophageal squamous cell carcinoma.
Zhu X
Oncology Reports, 35(3), 1664-1670 (2016)
Loss of DNA polymerase zeta causes chromosomal instability in mammalian cells.
Wittschieben JP
Cancer Research, 66(1), 134-142 (2006)
Knockdown of REV3 synergizes with ATR inhibition to promote apoptosis induced by cisplatin in lung cancer cells.
Jiang HG
Journal of Cellular Physiology, 232(12), 3433-3443 (2017)
Tris-(2,3-Dibromopropyl) Isocyanurate, a New Emerging Pollutant, Impairs Cognition and Provokes Depression-Like Behaviors in Adult Rats.
Ye L
PLoS ONE, 10(10), 1-16 (2015)
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