SAB4502713
Anti-SODIUM CHANNEL-PAN antibody produced in rabbit
affinity isolated antibody
别名:
CIN5, HH1, SCN5A, Sodium channel protein, cardiac muscle α-subunit
登录 查看组织和合同定价。
选择尺寸
关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 227 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SCN2A(6323)
正在寻找类似产品? 访问 产品对比指南
General description
Anti-SODIUM CHANNEL-PAN Antibody detects endogenous levels of total SODIUM CHANNEL-PAN protein.
The SCN5A (sodium channel protein type 5 subunit α) gene is mapped to human chromosome 3p22.2. The encoded protein is known to be localized to cardiac cells.
Immunogen
The antiserum was produced against synthesized peptide derived from human Sodium Channel.
Immunogen Range: 1466-1515
Immunogen Range: 1466-1515
Biochem/physiol Actions
SCN5A (sodium channel protein type 5 subunit α) is associated with the regulation of myocardial excitability as it conducts cardiac depolarization via inward Na+ current. Mutation in SCN5A causes retarded cardiac repolarization resulting in congenital long QT syndrome and also causes Brugada syndrome due to loss of gene function.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation.
Burel S
The Journal of Biological Chemistry, 292(42), 17431-17448 (2017)
Electrophysiological characterization of a large set of novel variants in the SCN5A-gene: identification of novel LQTS3 and BrS mutations.
Ortiz-Bonnin B
Pfluegers Archiv, 468(8), 1375-1387 (2016)
Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel.
Vikram A
Nature Medicine, 23(3), 361-367 (2017)
A common genetic variant within SCN10A modulates cardiac SCN5A expression.
van den Boogaard M
The Journal of Clinical Investigation, 124(4), 1844-1852 (2014)
Shehla U Hridi et al.
Molecular and cellular neurosciences, 95, 71-78 (2019-02-10)
Interleukin 16 (IL-16) is a cytokine that is primarily associated with CD4+ T cell function, but also exists as a multi-domain PDZ protein expressed within cerebellar and hippocampal neurons. We have previously shown that lymphocyte-derived IL-16 is neuroprotective against excitotoxicity
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持