SAB4502725
Anti-CHP2 antibody produced in rabbit
affinity isolated antibody
别名:
Calcineurin B homologous protein 2, Hepatocellular carcinoma-associated antigen 520
产品名称
Anti-CHP2 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 22 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CHP2(63928)
Biochem/physiol Actions
The protein encoded by CHP2 (calcineurin like EF-hand protein 2) gene serves as an important cofactor of Na+/H+ exchanger isoform 1 and maintains high intracellular pH in cancer cells. CHP2 protects cells from dying due to serum deprivation. Overexpression of the gene is observed in ovarian cancer and it is involved in the growth, proliferation, invasion and metastasis of cancer cells.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Anti-CHP2 antibody detects endogenous levels of total CHP2 protein.
The CHP2 (calcineurin like EF-hand protein 2) gene is mapped to human chromosome 16p12.2. It encodes a 23kDa protein containing myristoylation site at its N-terminal and four EF-hand Ca2+ binding motifs. The gene is predominantly expressed in small intestine and cancer cells.
Immunogen
The antiserum was produced against synthesized peptide derived from human CHP2.
Immunogen Range: 101-150
Immunogen Range: 101-150
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation.
Ammar YB
The Embo Journal, 25(11), 2315-2325 (2006)
Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1.
Ben Ammar Y
Acta Crystallographica Section F, Structural Biology and Crystallization Communications, 61(Pt 10), 956-958 (2005)
Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells.
Li QH
Genes Cells, 16(4), 416-426 (2011)
Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer.
Jin Q
In Vivo, 21(4), 593-598 (2007)
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