SAB4502850
抗 SREBP-1 兔抗
affinity isolated antibody
别名:
SRBP1, SREBF1, SREBP1, 甾醇调节元件结合蛋白1, 甾醇调节元件结合转录因子1
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
human, rat
Citations:
6
Technique(s):
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Uniprot accession no.:
产品名称
抗 SREBP-1 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 121 kDa
species reactivity
human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SREBF1(6720)
Biochem/physiol Actions
固醇调节元件结合蛋白-1（SREBP1）参与细胞脂质稳态的转录调节。它控制脂肪生成酶的肝基因表达和甘油三酸酯在肝脏中的沉积。
Disclaimer
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Features and Benefits
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General description
抗-SREBP-1抗体可检测总SREBP-1蛋白的内源性水平。
固醇调节元件结合蛋白-1（SREBP1）位于人类染色体17p11.2上。它属于bHLH-Zip转录因子家族。SREBP-1是由固醇调节的蛋白水解作用释放的膜结合转录因子。它是125 kD的前体，与核被膜和内质网结合。
Immunogen
该抗血清是针对衍生自人SREBP-1的合成肽而生成的。
免疫原范围： 405-454
免疫原范围： 405-454
Physical form
兔IgG，溶于磷酸盐缓冲液（不含Mg2+和Ca2+），pH 7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.
Wang X, et al.
Cell, 77(1), 53-62 (1994)
The membrane anchor of the transcriptional activator SREBP is characterized by intrinsic conformational flexibility.
Linser R, et al.
Proceedings of the National Academy of Sciences of the USA, 112(40), 12390-12395 (2015)
Absence of sterol regulatory element-binding protein-1 (srebp-1) ameliorates fatty livers but not obesity or insulin resistance inlep ob/lep ob mice.
Yahagi N, et al.
The Journal of Biological Chemistry, 277(22), 19353-19357 (2002)
Mathieu Schmitt et al.
Synapse (New York, N.Y.), 71(9) (2017-04-14)
The therapeutic use of statins has been associated to a reduced risk of Parkinson's disease (PD) and may hold neuroprotective potential by counteracting the degeneration of dopaminergic neurons. Transcriptional activation of the sterol regulatory element-binding protein (SREBP) is one of
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11. 2 and 22q13.
Hua X, et al.
Genomics, 25(3), 667-673 (1995)
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