SAB4502942
Anti-TIE2, C-Terminal antibody produced in rabbit
affinity isolated antibody
别名:
Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, hTIE2, p140 TEK
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunohistochemistry
immunohistochemistry
Species reactivity:
mouse, human
Citations:
5
Technique(s):
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
immunohistochemistry: 1:50-1:100
Uniprot accession no.:
产品名称
Anti-TIE2, C-Terminal antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 125 kDa
species reactivity
mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TEK(7010)
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Biochem/physiol Actions
Tie-2 (TEK receptor tyrosine kinase) protein induces angiogenesis (both developmental and tumor) and supports endothelial cell survival, upon binding of angiopoietin-1 (an endothelial growth factor) to the receptor. Tie-2 is necessary for Schlemm′s canal formation. The gene regulates vascular homeostasis by involving in auto or transphosphorylation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-TIE2 Antibody detects endogenous levels of total TIE2 protein.
The TIE2 (TEK receptor tyrosine kinase) gene is mapped to human chromosome 9p21.2. It is predominantly expressed in the Schlemm′s canal endothelial of the eye.
Immunogen
The antiserum was produced against synthesized peptide derived from human TIE2.
Immunogen Range: 1068-1117
Immunogen Range: 1068-1117
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma.
Kim J
The Journal of Clinical Investigation, 127(10), 3877-3896 (2017)
Angiopoietin-2 and soluble Tie-2 receptor plasma levels in children with obstructive sleep apnea and obesity.
Gozal D
Obesity (Silver Spring, Md.), 25(6), 1083-1090 (2017)
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.
Souma T
The Journal of Clinical Investigation, 126(7), 2575-2587 (2016)
Hisashi Takada et al.
Cancer science, 96(2), 100-110 (2005-02-23)
We performed genome-wide screening for deoxyribonucleic acid copy-number aberrations in 31 gastric cancer (GC) cell lines by using custom-made comparative genomic hybridization (CGH)-array. Copy-number gains were frequently detected at 1q, 3q, 5p, 7p, 7q, 8q, 11q, 17q, 20p, 20q, Xp
Jaeryung Kim et al.
Science advances, 5(2), eaau6732-eaau6732 (2019-02-23)
Choriocapillary loss is a major cause of neovascular age-related macular degeneration (NV-AMD). Although vascular endothelial growth factor (VEGF) blockade for NV-AMD has shown beneficial outcomes, unmet medical needs for patients refractory or tachyphylactic to anti-VEGF therapy exist. In addition, the
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