SAB4502945
Anti-Telomerase antibody produced in rabbit
affinity isolated antibody
别名:
EST2, HEST2, TCS1, Telomerase catalytic subunit, Telomerase reverse transcriptase
产品名称
Anti-Telomerase antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 126 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TERT(7015)
Biochem/physiol Actions
TERT (telomerase reverse transcriptase) catalyzes the de novo synthesis of telomere and results in cellular immortalization to maintain chromosomal stability. Mutations in TERT causes different types of malignancies such as gliomas, gastric cancer, and anaplastic thyroid cancer. Therefore, TERT serves as an early prognostic biomarker.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-Telomerase Antibody detects endogenous levels of total Telomerase protein.
The TERT (telomerase reverse transcriptase) gene is mapped to human chromosome 5p15.33 and encodes for a ribonucleoprotein.
Immunogen
The antiserum was produced against synthesized peptide derived from human Telomerase.
Immunogen Range: 796-845
Immunogen Range: 796-845
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma.
Carkic J
Journal of Oral Science, 58(4), 449-458 (2016)
Silencing of hTERT blocks growth and migration of anaplastic thyroid cancer cells.
Maggisano V
Molecular and Cellular Endocrinology, 448, 34-40 (2017)
Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas.
Fan X
Journal of Neuro-Oncology, 28(3), 455-462 (2016)
Lung cancer susceptibility locus at 5p15.33.
McKay JD
Nature Genetics, 40(12), 1404-1406 (2008)
Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression.
Tang B
Oncotarget, 7(10), 11364-11379 (2016)
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