SAB4503022
Anti-C1S, C-Terminal antibody produced in rabbit
affinity isolated antibody
别名:
C1 esterase, C1S, Complement C1s subcomponent, Complement component 1 subcomponent s
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
6
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 76 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... C1S(716)
General description
Anti-C1S Antibody detects endogenous levels of total C1S protein.
The C1S (complement C1s) gene is mapped to human chromosome 12p13 and codes for a subcomponent of C1 complex of the classical pathway.
Immunogen
The antiserum was produced against synthesized peptide derived from human C1S.
Immunogen Range: 541-590
Immunogen Range: 541-590
Biochem/physiol Actions
Activation of C1s (complement C1s) along with C1r triggers complement cascade. C1s is responsible for the cleavage of complement component C4 and C2, which is necessary for complete activation of complement system. Studies determined that C1s specifically acts on Val or Leu at P(3) and Ala or Gly residues at P(2) positions. The C1S gene is known to be associated with lupus nephritis, with low gene expression observed in mice.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4
Perry AJ
The Journal of Biological Chemistry, 288(22), 15821?15829-15821?15829 (2013)
Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s.
Duncan RC
Journal of Immunology, 189(5), 2365-2373 (2012)
Gene expression analysis detected a low expression level of C1s gene in ICR-derived glomerulonephritis (ICGN) mice
Tamura K
Nephron: Experimental Nephrology, 123(3-4), 34-45 (2013)
Elucidation of the substrate specificity of the C1s protease of the classical complement pathway.
Kerr FK
The Journal of Biological Chemistry, 280(47), 39510-39514 (2005)
Complement genetics, deficiencies, and disease associations
Mayilyan KR
Protein & cell, 3(7), 487?496-487?496 (2012)
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