SAB4503272
Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit
affinity isolated antibody
别名:
ICE, IL-1 β, IL-1 β converting enzyme, IL-1BC, caspase-1
产品名称
Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 25 kDa
antigen 45 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
proteolytically cleaved (Asp210)
Quality Level
Gene Information
human ... CASP1(834)
Biochem/physiol Actions
Caspase-1 can transform pro-inflammatory cytokines, interleukin-1β (IL-1β) and interleukin-18 (IL-18) into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients. CASP-1 helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-CASP-1 (Cleaved-Asp210) Antibody detects endogenous levels of fragment of activated CASP-1 (Cleaved-Asp210) protein.
Caspase-1 is also known as interleukin-1β converting enzyme (ICE). It is located on human chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. CASP-1 is present in leukocytes, monocytes and epithelial cells.
Immunogen
The antiserum was produced against synthesized peptide derived from human IL-1 beta.
Immunogen Range: 161-210
Immunogen Range: 161-210
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1.
Shamaa OR, et al.
PLoS ONE, 10(11) (2015)
CASP1 (caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)).
Kumar Y, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2008)
Overexpression of caspase-1 in aorta of patients with coronary atherosclerosis
Zheng F, et al.
Heart, Lung & Circulation, 23(11), 1070-1074 (2014)
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