SAB4503399
Anti-LAT3 antibody produced in rabbit
affinity isolated antibody
别名:
L-type amino acid transporter 3, Prostate cancer overexpressed gene 1 protein, SLC43A1, Solute carrier family 43 member 1
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NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 61 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLC43A1(8501)
General description
Anti-LAT3 Antibody detects endogenous levels of total LAT3 protein.
LAT3/SLC43A1 (solute carrier family 43 member 1), a Na+-independent neutral L-amino acid transporter, is mapped to human chromosome 11q12.1. It is expressed in liver, skeletal muscle and pancreas.
Immunogen
The antiserum was produced against synthesized peptide derived from human LAT3.
Immunogen Range: 231-280
Immunogen Range: 231-280
Biochem/physiol Actions
LAT3/SLC43A1 (solute carrier family 43 member 1) is essential for the growth and activities of podocytes. In prostate cancer cell lines, silencing the expression of LAT3 stops the initiation of mTORC1 (mammalian target of rapamycin complex 1) pathway activation, cell growth and cell cycle both in vitro and in vivo.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Monoterpene glycoside ESK246 from Pittosporum targets LAT3 amino acid transport and prostate cancer cell growth
Wang Q, et al.
ACS Chemical Biology, 9(6), 1369-1376 (2014)
Amino acid transporter LAT3 is required for podocyte development and function
Sekine Y, et al.
Journal of the American Society of Nephrology, 20(7), 1586-1596 (2009)
Genome-wide analysis of pancreatic cancer using microarray-based techniques.
Harada T
Pancreatology : Official Journal of the International Association of Pancreatology (Iap) ... [Et Al.], 9(1-2), 13-24 (2009)
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