SAB4503405
Anti-HAT antibody produced in rabbit
affinity isolated antibody
别名:
KAT1, histone acetyltransferase 1, histone acetyltransferase type B catalytic
产品名称
Anti-HAT antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 49 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HAT1(8520)
Application
Anti-HAT antibody produced in rabbit has been used in western blotting (1:500) and immunofluorescence (1:250).
Biochem/physiol Actions
Histone acetyltransferase 1 (HAT1) is involved in the acetylation of lysine 5- and 12- residues at the N-terminal of the newly synthesized histone H4. This enzyme is also involved in the regulation of DNA repair in the nucleus.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase localized in the cytosol and the nucleus. The HAT1 gene is mapped on the human chromosome at 2q31.1.
Immunogen
The antiserum was produced against synthesized peptide derived from human HAT.
Immunogen Range: 331-380
Immunogen Range: 331-380
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Xiaohan Yang et al.
The Journal of biological chemistry, 288(25), 18271-18282 (2013-05-09)
Faithful repair of DNA double-strand breaks is vital to the maintenance of genome integrity and proper cell functions. Histone modifications, such as reversible acetylation, phosphorylation, methylation, and ubiquitination, which collectively contribute to the establishment of distinct chromatin states, play important
Hirak Kumar Barman et al.
Biochemical and biophysical research communications, 373(4), 624-630 (2008-07-08)
Amounts of soluble histones in cells are tightly regulated to ensure supplying them for the newly synthesized DNA and preventing the toxic effect of excess histones. Prior to incorporation into chromatin, newly synthesized histones H3 and H4 are highly acetylated
Josef Davidsson et al.
Epilepsy research, 81(1), 69-79 (2008-06-10)
To characterize a deletion of chromosome 2q at the molecular level in a patient suffering from severe epilepsy resembling severe myoclonic epilepsy of infancy/Dravet's syndrome (SMEI/DS) and to correlate other cases harboring deletions in the same region to morphological and
Yueqin Wang et al.
Chemosphere, 241, 125073-125073 (2019-11-07)
Microcystin-leucine arginine (MC-LR) is a variant of microcystins (MCs), which poses a serious threat to the reproductive system. Histone acetylation modification can regulate the expressions of apoptosis-related genes. However the mechanisms of histone acetylation involving MC-LR-induced apoptosis were not understood.
S V Demyanenko et al.
Molecular neurobiology, 57(7), 3219-3227 (2020-06-09)
Stroke is one of the leading reasons of human death. Ischemic penumbra that surrounds the stroke-induced infarction core is potentially salvageable, but molecular mechanisms of its formation are poorly known. Histone acetylation induces chromatin decondensation and stimulates gene expression. We
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