SAB4503508
Anti-WAVE1 antibody produced in rabbit
affinity isolated antibody
别名:
KIAA0269, SCAR1, Verprolin homology domain-containing protein 1, WAS1, WASF1
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC, WB
Citations:
8
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 61 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... WASF1(8936)
General description
Wiskott–aldrich syndrome protein family member 1 (WAVE1) is encoded by the gene mapped to human chromosome 6q21-22. It is primarily expressed in brain and is characterized with a tripartite VCA (verprolin homology, cofilin homology and acidic) domain.
Immunogen
The antiserum was produced against synthesized peptide derived from human WAVE1.
Immunogen Range: 91-140
Immunogen Range: 91-140
Application
Anti-WAVE1 antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Members of WASP-family verprolin-homologous protein (WAVE) family plays a vital role in actin polymerisation and cytoskeletal organisation, which are essential for various cellular processes, including cell shape changes, cytokinesis, cell motility and membrane traffic. WAVE1 regulates chemoresistance during autophagy. The encoded protein plays an essential role in oligodendrocyte morphogenesis and myelination. In addition, it is also implicated in regulation of spine morphogenesis. Overexpression of the gene leads to the development of prostate cancer.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology.
Kim Y, et al.
Nature, 442(7104), 814-814 (2006)
Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.
Suetsugu S, et al.
Biochemical and Biophysical Research Communications, 260(1), 296-302 (1999)
Expression of the WASP verprolin-homologues (WAVE members) in human breast cancer.
Fernando H S, et al.
Oncology, 73(5-6), 376-383 (2007)
Knockdown of WAVE1 enhances apoptosis of leukemia cells by downregulating autophagy.
Zhang Z, et al.
International Journal of Oncology, 48(6), 2647-2656 (2016)
WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.
Kim H J, et al.
The Journal of Neuroscience, 26(21), 5849-5859 (2006)
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