Anti-EXO1 antibody produced in rabbit

Anti-EXO1 Antibody detects endogenous levels of total EXO1 protein.

Exonuclease 1 (EXO1), a member of RAD2 nuclease family, comprises an amino-terminal (N) domain, intermediate spacer region and an internal (I) domain with cysteine and glutamate residues. The Exo 1 gene is mapped to human chromosome 1q43.

The antiserum was produced against synthesized peptide derived from human EXO1.

Immunogen Range: 61-110

Anti-EXO1 antibody produced in rabbit has been used in immunoblotting.

Exonuclease 1 (EXO1) N-domain mediates the DNA binding and the I domain is crucial for magnesium binding. It displays micro-mediated end-joining, 5′ to 3′ exonuclease activity and mediates homologous recombination and replication. EXO1 is more efficient on single-stranded DNA (ssDNA) than double-stranded DNA in exonucleolytic degradation. It also exhibits 5′ ssDNA-flap-specific endonuclease activity. EXO1 polymorphisms may be implicated in epithelial ovarian cancer (EOC).

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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