SAB4503570
Anti-DGKI antibody produced in rabbit
affinity isolated antibody
别名:
DAG kinase ι, DGK-ι, DGKI, diacylglycerol kinase
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NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 116 kDa
species reactivity
rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DGKI(9162)
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General description
Anti-DGKI Antibody detects endogenous levels of total DGKI protein.
DGKI (Diacylglycerol kinase iota) is a small, integral membrane protein belonging to the type IV diacylglycerol kinase subfamily. It is mapped on chromosome 7q32.3-q33. The members of the DGK family consist of a catalytic domain and at least two cysteine-rich regions. In type IV family members, it has four ankyrin repeats and a carboxy terminal PDZ binding domain.
Immunogen
The antiserum was produced against synthesized peptide derived from human DGKI.
Immunogen Range: 991-1040
Immunogen Range: 991-1040
Application
Anti-DGKI, C-Terminal antibody produced in rabbit is suitable for indirect immunofluorescence and western blot.
Biochem/physiol Actions
DGKI (Diacylglycerol kinase iota) is mainly involved in the maintenance of intracellular concentration of diacylglycerol by phosphorylating other lipids in addition to DAG. DGKI has been predicted to be a potential gene for tumor suppression in colorectal cancers and mutation in DGKI has been linked to the melanoma.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The Role of Chromosomal Instability and Epigenetics in Colorectal Cancers Lacking ??-Catenin/TCF Regulated Transcription
Wael M Abdel-Rahman, et al.
Gastroenterology Research and Practice (2016)
Matthew K Topham et al.
Biochimica et biophysica acta, 1790(6), 416-424 (2009-04-15)
The mammalian diacylglycerol kinases (DGK) are a group of enzymes having important roles in regulating many biological processes. Both the product and the substrate of these enzymes, i.e. diacylglycerol and phosphatidic acid, are important lipid signalling molecules. Each DGK isoform
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