生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 116 kDa
种属反应性
rat, human
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... DGKI(9162)
一般描述
Anti-DGKI Antibody detects endogenous levels of total DGKI protein.
DGKI (Diacylglycerol kinase iota) is a small, integral membrane protein belonging to the type IV diacylglycerol kinase subfamily. It is mapped on chromosome 7q32.3-q33. The members of the DGK family consist of a catalytic domain and at least two cysteine-rich regions. In type IV family members, it has four ankyrin repeats and a carboxy terminal PDZ binding domain.
免疫原
The antiserum was produced against synthesized peptide derived from human DGKI.
Immunogen Range: 991-1040
Immunogen Range: 991-1040
应用
Anti-DGKI, C-Terminal antibody produced in rabbit is suitable for indirect immunofluorescence and western blot.
生化/生理作用
DGKI (Diacylglycerol kinase iota) is mainly involved in the maintenance of intracellular concentration of diacylglycerol by phosphorylating other lipids in addition to DAG. DGKI has been predicted to be a potential gene for tumor suppression in colorectal cancers and mutation in DGKI has been linked to the melanoma.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
The Role of Chromosomal Instability and Epigenetics in Colorectal Cancers Lacking ??-Catenin/TCF Regulated Transcription
Wael M Abdel-Rahman, et al.
Gastroenterology Research and Practice (2016)
Matthew K Topham et al.
Biochimica et biophysica acta, 1790(6), 416-424 (2009-04-15)
The mammalian diacylglycerol kinases (DGK) are a group of enzymes having important roles in regulating many biological processes. Both the product and the substrate of these enzymes, i.e. diacylglycerol and phosphatidic acid, are important lipid signalling molecules. Each DGK isoform
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