产品名称
Anti-ARHGEF10 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 151 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ARHGEF10(9639)
Biochem/physiol Actions
ARHGEF10 (Rho guanine nucleotide exchange factor 10) works as a guanine nucleotide exchange factor for RhoA, RhoB and RhoC. It is involved in atherosclerotic cerebral infarction and mutation in ARHGEF10 is associated with increased risk of atherothrombotic stroke. Mutation in ARFGEF10 is also linked with slowed nerve conduction velocities and thin myelination of peripheral nerves.
Features and Benefits
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General description
Anti-ARHGEF10 Antibody detects endogenous levels of total ARHGEF10 protein.
The gene ARHGEF10 (Rho guanine nucleotide exchange factor 10) is mapped to human chromosome 8p23. It belongs to the Rho-specific guanine nucleotide exchange factor family. The protein contains tandem Dbl homology (DH) domain, pleckstrin homology (PH) domain and putative transmembrane domains.
The gene ARHGEF10 (Rho guanine nucleotide exchange factor 10) is mapped to human chromosome 8p23. It belongs to the Rho-specific guanine nucleotide exchange factor family. The protein contains tandem Dbl homology (DH) domain, pleckstrin homology (PH) domain and putative transmembrane domains.
Immunogen
The antiserum was produced against synthesized peptide derived from human ARHGEF10.
Immunogen Range: 339-388
Immunogen Range: 339-388
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Kristien Verhoeven et al.
American journal of human genetics, 73(4), 926-932 (2003-09-26)
Slowed nerve-conduction velocities (NCVs) are a biological endophenotype in the majority of the hereditary motor and sensory neuropathies (HMSN). Here, we identified a family with autosomal dominant segregation of slowed NCVs without the clinical phenotype of HMSN. Peripheral-nerve biopsy showed
Taro Chaya et al.
The Journal of biological chemistry, 286(34), 29511-29520 (2011-07-02)
The T332I mutation in Rho guanine nucleotide exchange factor 10 (ARHGEF10) was previously found in persons with slowed nerve conduction velocities and thin myelination of peripheral nerves. However, the molecular and cellular basis of the T332I mutant is not understood.
Yan-Ying Yin et al.
Neurology India, 59(3), 408-412 (2011-07-12)
The gene encoding RhoA guanine nucleotide exchange factor 10(ARHGEF10) has been reported to be a risk factor for atherothrombotic stroke (AS) in Japanese. The single-nucleotide polymorphism (SNP) rs4376531 in intron 16 on ARHGEF10 is associated with AS and may play
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