产品名称
抗 E-钙黏蛋白 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 97 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CDH1(999)
Application
抗 E-钙粘蛋白、N-末端抗体可用于蛋白提取、蛋白质印迹、共聚焦荧光显微镜分析、免疫染色和免疫共沉淀。
Biochem/physiol Actions
CDH1(钙粘蛋白 1)有助于保存上皮组织中嗜同性细胞间粘附(homophilic cell-cell adhesion)。CDH1 表达不足导致结肠癌 和肾细胞癌 (RCC)。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完全放心地试用我们的抗体。如果抗体在您的申请的研究中不起作用,我们将全额退款或安排替代抗体。了解更多。
General description
CDH1(钙粘蛋白 1)编码位于人类染色体 16q22.1 的跨膜糖蛋白 E-钙粘蛋白。它是一种肿瘤抑制基因,也被称为 Cdh1p/Hct1p、fizz-related、Ste9 或 Srw1。
抗 E-钙粘蛋白抗体检测内源性总 E-钙粘蛋白水平。
Immunogen
抗血清是针对合成的人 E-钙粘蛋白肽。
免疫原范围:1-50
免疫原范围:1-50
Physical form
兔 IgG 溶于磷酸盐缓冲盐水(不含 Mg2+ 和 Ca2+),pH7.4,150mM NaCl,0.02% 叠氮化钠和 50% 甘油中。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Sal-like 4 (SALL4) suppresses CDH1 expression and maintains cell dispersion in basal-like breast cancer
Itou J, et al.
Febs Letters, 587(18), 3115-3121 (2013)
CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer
Caldeira JR, et al.
BMC Cancer (2006)
Junji Itou et al.
FEBS letters, 587(18), 3115-3121 (2013-08-21)
In cell cultures, the dispersed phenotype is indicative of the migratory ability. Here we characterized Sal-like 4 (SALL4) as a dispersion factor in basal-like breast cancer. Our shRNA-mediated SALL4 knockdown system and SALL4 overexpression system revealed that SALL4 suppresses the
miR-216a inhibits osteosarcoma cell proliferation, invasion and metastasis by targeting CDK14
Ji Q, et al.
Cell Death & Disease (2017)
Mitotic Regulation of the APC Activator Proteins CDC20 and CDH1
Kramer ER, et al.
Molecular Biology of the Cell (2000)
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