SAB4503882
Anti-phospho-IKK-α (pSer176) /IKK-β (pSer177) antibody produced in rabbit
affinity isolated antibody
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
7
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 84 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer176/pSer177)
Quality Level
Gene Information
human ... CHUK(1147), IKBKB(3551)
General description
CHUK (conserved helix-loop-helix ubiquitous kinase) is located on human chromosome 10q24. IKK1/IKK-α has three ordered protein domains, namely, a kinase domain (KD), a ubiquitin-like domain (ULD) and a scaffold dimerization domain (SDD). IKKB (inhibitor of nuclear factor κ B kinase subunit β) is mapped to human chromosome 8p11. IKBKB codes for IκB kinase 2 (IKK2/IKKβ). IKK1 and IKK2 has a canonical MAP kinase kinase (MAPKK) activation loop motif.
Immunogen
The antiserum was produced against synthesized peptide derived from human IKK-alpha around the phosphorylation site of Ser177.
Immunogen Range: 151-200
Immunogen Range: 151-200
Biochem/physiol Actions
IKK1/IKKα (I-κ-B kinase 1) modulates nuclear factor κ-B (NF-κB) signaling, that is required for lymphoid organogenesis and adaptive immunity. IκB kinase α (IKKα) plays a major role in human skin cancer. This gene also controls terminal differentiation and multiplication of keratinocytes. IKKβ acts as the master regulator of cell survival and the inflammatory response.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Chapter 252 - NFκB: A Key Integrator of Cell Signaling
Handbook of Cell Signaling, 2069-2076 (2009)
A suite of novel human spermatozoal RNAs.
Ostermeier G C, et al.
Journal of Andrology, 26(1), 70-74 (2005)
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
Reid M A, et al.
Genes & Development, 30(16), 1837?1851-1837?1851 (2016)
Structural Basis for the Activation of IKK1/α.
Polley S, et al.
Cell Reports, 17(8), 1907-1914 (2016)
I?B kinase α functions as a tumor suppressor in epithelial-derived tumors through an NF-κB-independent pathway.
Xie Y, et al.
Oncology Reports, 34(5), 2225-2232 (2015)
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