生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 156 kDa
种属反应性
mouse, rat, human
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pTyr1355)
基因信息
human ... INSR(3643)
一般描述
Insulin receptor (INSR) is located on human chromosome 19. It has 22 exons spanning 120 kilobases. The gene product of INSR has a leader sequence of 27 amino acids.
免疫原
The antiserum was produced against synthesized peptide derived from human IR around the phosphorylation site of Tyr1355.
Immunogen Range: 1326-1375
Immunogen Range: 1326-1375
生化/生理作用
Insulin binds to its receptor (INSR) or to the structurally related insulin-like growth factor-I receptor (IGFIR) to control the development and apoptosis of cells. Aberrations in exon 17 of insulin receptor (INSR) gene result in PCOS (polycystic ovary syndrome). It plays a key role in insulin metabolism. Mutations in INSR results in insulin-resistant syndromes like leprechaunism (donohue syndrome), rabson–mendenhall syndrome and type A insulin resistance.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Family association study between INSR gene polymorphisms and PCOS in Han Chinese.
Xu X, et al.
Reproductive Biology and Endocrinology, 9(1), 76-76 (2011)
Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect.
Pechlivanis S, et al.
Endocrine-Related Cancer, 14(3), 733-740 (2007)
Sequencing analysis of insulin receptor defects and detection of two novel mutations in INSR gene.
Ardon O, et al.
Molecular genetics and metabolism reports, 1, 71-84 (2014)
A novel SNP at exon 17 of INSR is associated with decreased insulin sensitivity in Chinese women with PCOS.
Jin L, et al.
Molecular Human Reproduction, 12(3), 151-155 (2006)
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