生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 6 kDa
种属反应性
human, rat, mouse
浓度
~1 mg/mL
技术
ELISA: 1:1000
immunofluorescence: 1:100-1:500
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer16/pThr17)
基因信息
human ... PLN(5350)
一般描述
Phospholamban (PLN) gene codes for a small integral membrane protein. It is located on human chromosome 6q22.1. PLN is a 52-amino-acid phosphoprotein.
免疫原
The antiserum was produced against synthesized peptide derived from human PLB around the phosphorylation site of Ser16 and Thr17.
Immunogen Range: 1-50
Immunogen Range: 1-50
生化/生理作用
Phospholamban (PLN) participates in calcium signalling and muscle contraction. This protein regulates the activity of the sarcoplasmic reticulum Ca2+-ATPase (SERCA) of cardiac myocytes. Mutations in the phospholamban (PLN) gene result in dilated cardiomyopathy (DCM) and severe heart failure.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.
Haghighi K, et al.
The Journal of Clinical Investigation, 111(6), 869-876 (2003)
Diagnostic, prognostic, and therapeutic implications of genetic testing for hypertrophic cardiomyopathy.
Bos J M, et al.
Journal of the American College of Cardiology, 54(3), 201-211 (2009)
Phospholamban spontaneously reconstitutes into giant unilamellar vesicles where it generates a cation selective channel.
Smeazzetto S, et al.
Physical Chemistry Chemical Physics, 18(3), 1629-1636 (2016)
Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies.
Fish M, et al.
Scientific Reports, 6, 22235-22235 (2016)
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