biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 68 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000, immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pThr210)
Quality Level
Gene Information
human ... PLK1(5347)
General description
Human polo-like kinase 1 (PLK1) is a serine/threonine kinase, that is located on human chromosome 16p12.
Immunogen
The antiserum was produced against synthesized peptide derived from human PLK1 around the phosphorylation site of Thr210.
Immunogen Range: 176-225
Immunogen Range: 176-225
Biochem/physiol Actions
Polo-like kinase 1 (PLK1) plays an important role in the functional maturation of mitotic centrosomes. It actively participates in the development of the cell cycle. This gene is considered as an important therapeutic target as it is overexpressed in several cancer types.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes
H A Lane and E A Nigg
The Journal of Cell Biology, 1701-1713 (1996)
Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors
Kolberg M, et al.
Molecular Oncology, 11(9), 1156-1171 (2017)
Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1
Petronczki M, et al.
Developmental Cell, 14(5), 646-659 (2008)
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