SAB4503999
抗-磷酸-TIE2 (pTyr1108) 兔抗
affinity isolated antibody
别名:
Anti-CD202B, Anti-GLC3E, Anti-TIE-2, Anti-VMCM, Anti-VMCM1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Species reactivity:
mouse, rat, human
Citations:
7
Technique(s):
ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
Uniprot accession no.:
产品名称
抗-磷酸-TIE2 (pTyr1108) 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 125 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr1108)
Quality Level
Gene Information
human ... TEK(7010)
Biochem/physiol Actions
血管生成素-1（一种内皮生长因子）结合后，TIE2受体（TEK受体酪氨酸激酶）可诱导血管生成和支持内皮细胞存活。该基因是Schlemm管形成所必需的。该基因通过自体或转移磷酸化调节血管稳态。Tie-2是胚胎生成期间血管结构形成的重要因子。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
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General description
TIE2（TEK受体酪氨酸激酶）也称为TEK（酪氨酸蛋白激酶受体）。基因位于人染色体9p21.2。蛋白表达于眼睛的Schlemm管内皮细胞。TIE2属于受体酪氨酸激酶家族。
Immunogen
抗血清由人TIE2中围绕Tyr1108磷酸化位点的一段序列来源的合成肽生产。
免疫原范围： 1074-1123
免疫原范围： 1074-1123
Physical form
兔IgG，溶于磷酸盐缓冲液（不含Mg2+和Ca2+），pH 7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation
Hossain MB, et al.
Molecular and Cellular Biology (2017)
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
Davis S, et al.
Cell, 87(7), 1161-1169 (1996)
Hui Liu et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 54(10), e11028-e11028 (2021-07-22)
Engeletin is a natural derivative of Smilax glabra rhizomilax that exhibits anti-inflammatory activity and suppresses lipid peroxidation. In the present study, we sought to elucidate the mechanistic basis for the neuroprotective and pro-angiogenic activity of engeltin in a human umbilical
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
Suri C, et al.
Cell, 87(7), 1171-1180 (1996)
Angiopoietin-2 and soluble Tie-2 receptor plasma levels in children with obstructive sleep apnea and obesity.
Gozal D
Obesity (Silver Spring, Md.), 25(6), 1083-1090 (2017)
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