生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 109 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pTyr594/pTyr604)
基因信息
human ... EPHA2(1969), EPHB1(2047)
一般描述
EPHB1(ephrin type-B receptor 1) and EPHA2 (EPH receptor A2) belongs to the Eph gene family of receptor tyrosine kinases. EPHB1 is present in venous endothelial cells during embryonic development to adulthood. It is located on human chromosome 3q22.2. EPH receptor A2 codes for a 976 amino acid, type-1 transmembrane protein with extracellular NH2-terminal and cytoplasmic COOH-terminal halves.
免疫原
The antiserum was produced against synthesized peptide derived from human EPHB1/2 around the phosphorylation site of Tyr594/604.
Immunogen Range: 561-610
Immunogen Range: 561-610
生化/生理作用
EPHB1(ephrin type-B receptor 1) participates in carcinogenesis of RCC (renal cell carcinoma). EPHB1 plays a major role in the growth of nervous and vascular systems. It acts as a biomarker for squamous cell/adenosquamous carcinomas and adenocarcinomas of the gallbladder. EPHA2 (EPH receptor A2) gene is associated with cataracts.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Loss of expression of EphB1 protein in serous carcinoma of ovary associated with metastasis and poor survival
Wang H, et al.
International Journal of Clinical and Experimental Pathology, 7(1), 313-321 (2013)
Decreased expression of receptor tyrosine kinase of EphB1 protein in renal cell carcinomas
Zhou S, et al.
International Journal of Clinical and Experimental Pathology, 7(7), 4254-4260 (2014)
The EPHA2 gene is associated with cataracts linked to chromosome 1p
Shiels A, et al.
Molecular Vision, 14, 2042-2055 (2008)
EphB1 and Ephrin-B, new potential biomarkers for squamous cell/adenosquamous carcinomas and adenocarcinomas of the gallbladder
Yuan Y, et al.
Asian Pacific Journal of Cancer Prevention, 15(3), 1441-1446 (2014)
Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival
Lake SL, et al.
The American Journal of Pathology, 182(3), 678-687 (2013)
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