Anti-phospho-HDAC6 (pSer²²) antibody produced in rabbit

Histone deacetylases 6 (HDAC6) is encoded by the gene mapped to human chromosome Xp11.23. It belongs to the class IIb histone deacetylase family of enzymes, that remove acetyl groups from lysine residues. This protein is present mainly in cytosol.

The antiserum was produced against synthesized peptide derived from human HDAC6 around the phosphorylation site of Ser22.

Immunogen Range: 7-56

Histone deacetylases 6 (HDAC6) is associated with various cellular processes such as regulation of microtubules, growth factor-induced chemotaxis, misfolded protein stress response, and tumor invasion. Increased expression of HDAC6 might promote tumorigenesis by upregulating the expression of c-myc. Overexpression of HDAC6 is seen in acute myeloid leukemia and some breast cancer patients. Oncogenic K-ras imparts suberoylanilide hydroxamic acid (SAHA) resistance via increasing HDAC6 and c-myc expression. HDAC6 controls cellular protective response against cytotoxic accumulation of toxic bioproducts. HDAC6 Inhibition is considered to be a potential therapeutic strategy for treating inflammatory breast cancer (IBC) patients. HDAC6 and acetylated α-tubulin play a vital role in regulation of adipocyte differentiation.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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