产品名称
Anti-phospho-RAD51 (pTyr315) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 36 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr315)
Quality Level
Gene Information
human ... RAD51(5888)
Application
Anti-phospho-RAD51 (pTyr315) antibody has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
RAD51 (RAD51 recombinase) plays a major role in homology-directed repair (HDR) and cell viability.This gene acts an an important target for cancer therapy. RAD51 interacts with BRCA2 (breast cancer susceptibility protein) and participates in DSB (double strand DNA breaks) repair.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
RAD51 (RAD51 recombinase) belongs to the RecA/RadA/Rad51 protein family. It has a conserved ATP binding core. This protein is expressed in testis, ovary, and lymphoid tissue. It is located on human chromosome 15q15.
Immunogen
The antiserum was produced against synthesized peptide derived from human RAD51 around the phosphorylation site of Tyr315.
Immunogen Range: 281-330
Immunogen Range: 281-330
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
A cell-penetrating antibody inhibits human RAD51 via direct binding
Turchick A, et al.
Nucleic Acids Research, 45(20), 11782-11799 (2017)
Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability
Mirza S, et al.
Cell Cycle, 11(22), 4266-4274 (2012)
The Rad51/RadA N-terminal domain activates nucleoprotein filament ATPase activity.
Galkin VE, et al.
Structure, 14(6), 983-992 (2006)
Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations.
Gonzalez R, et al.
British Journal of Cancer, 81(3), 503-509 (1999)
RAD51, BRCA2 and DNA repair: a partial resolution.
Lord CJ and Ashworth A
Nature Structural and Molecular Biology, 14(6), 461-462 (2007)
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