SAB4504289
Anti-phospho-p47 phox (pSer359) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-CGD1, Anti-NCF1A, Anti-NOXO2, Anti-SH3PXD1A, Anti-p47phox
产品名称
Anti-phospho-p47 phox (pSer359) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 44 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer359)
Quality Level
Gene Information
human ... NCF1(653361)
Biochem/physiol Actions
NCF1 (neutrophil cytosolic factor-1) is an important constituent of the phagocyte NADPH-oxidase system. The enzyme helps in the synthesis of microbicidal superoxide in phagocytes like neutrophil and plays a key role in host defense against microbial pathogens. A 2-bp GT deletion in exon 2 of the NCF1 gene results in chronic granulomatous disease (CGD).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Phospho-p47/ NCF1 (neutrophil cytosolic factor-1) codes for the p47phox subunit of the phagocyte NADPH oxidase (NOX2). It is a cytosolic factor. This gene is located with two pseudogenes (NCF1B and NCF1C). NCF1 is mapped to human chromosome 7q11.23.
Immunogen
The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser359.
Immunogen Range: 331-380
Immunogen Range: 331-380
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.
Zhao J, et al.
Nature Genetics, 49(3), 433-437 (2017)
Genomic structure of the human p47-phox (NCF1) gene.
Chanock SJ, et al.
Blood Cells, Molecules and Diseases, 26(1), 37-46 (2000)
A copy number variation in human NCF1 and its pseudogenes.
Brunson T, et al.
BMC Genetics, 11(1), 13-13 (2010)
Glaucy Rodrigues de Araújo et al.
Experimental biology and medicine (Maywood, N.J.), 242(3), 333-343 (2017-01-21)
Baccharis trimera, popularly known as "carqueja", is a native South-American plant possessing a high concentration of polyphenolic compounds and therefore high antioxidant potential. Despite the antioxidant potential described for B. trimera, there are no reports concerning the signaling pathways involved
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