产品名称
Anti-phospho-Cortactin (pTyr421) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 61 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr421)
Quality Level
Gene Information
human ... CTTN(2017)
Application
Anti-phospho-Cortactin (pTyr421) antibody has been used in western blotting and immunoprecipitation.
Biochem/physiol Actions
Cortactin controls Arp2/3-mediated actin polymerization. This protein also modulates aggressive cancer cell traits like tumor growth, cancer cell invasion and motility, and serum- and anchorage-independent growth.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Cortactin is an actin-related protein 2/3 (Arp2/3) complex–activating and filamentous (F)-actin–binding protein. This protein is coded by CTTN gene that maps to human chromosome 11q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human Cortactin around the phosphorylation site of Tyr421.
Immunogen Range: 388-437
Immunogen Range: 388-437
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Cyclic expression of the voltage?gated potassium channel KV10. 1 promotes disassembly of the primary cilium.
Sanchez A, et al.
EMBO Reports, e201541082-e201541082 (2016)
β3 integrin expression is required for invadopodia-mediated ECM degradation in lung carcinoma cells.
Pelaez R, et al.
PLoS ONE, 12(8), e0181579-e0181579 (2017)
Araceli Sánchez et al.
EMBO reports, 17(5), 708-723 (2016-04-27)
The primary cilium, critical for morphogenic and growth factor signaling, is assembled upon cell cycle exit, but the links between ciliogenesis and cell cycle progression are unclear. KV10.1 is a voltage-gated potassium channel frequently overexpressed in tumors. We have previously
Cortactin promotes exosome secretion by controlling branched actin dynamics.
Sinha S, et al.
The Journal of Cell Biology, 214(2), 197-213 (2016)
Cortactin contributes to the tumorigenicity of colorectal cancer by promoting cell proliferation.
Wu H, et al.
Oncology Reports, 36(6), 3497-3503 (2016)
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