生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 61 kDa
种属反应性
human, rat, mouse
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pTyr466)
基因信息
mouse ... Cttn(13043)
一般描述
Cortactin is an actin-related protein 2/3 (Arp2/3) complex–activating and filamentous (F)-actin–binding protein. This protein is coded by CTTN gene that maps to human chromosome 11q13.
免疫原
The antiserum was produced against synthesized peptide derived from mouse Cortactin around the phosphorylation site of Tyr466.
Immunogen Range: 441-490
Immunogen Range: 441-490
应用
Anti-phospho-Cortactin (pTyr421) antibody has been used in western blotting and immunoprecipitation.
生化/生理作用
Cortactin controls Arp2/3-mediated actin polymerization. This protein also modulates aggressive cancer cell traits like tumor growth, cancer cell invasion and motility, and serum and anchorage-independent growth.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Anita Kumari et al.
Nature communications, 10(1), 2870-2870 (2019-06-30)
An important channel of cell-to-cell communication is direct contact. The immune synapse is a paradigmatic example of such type of interaction: it forms upon engagement of antigen receptors in lymphocytes by antigen-presenting cells and allows the local exchange of molecules
Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification.
Rothschild B L, et al.
Cancer Research, 66(16), 8017-8025 (2006)
Araceli Sánchez et al.
EMBO reports, 17(5), 708-723 (2016-04-27)
The primary cilium, critical for morphogenic and growth factor signaling, is assembled upon cell cycle exit, but the links between ciliogenesis and cell cycle progression are unclear. KV10.1 is a voltage-gated potassium channel frequently overexpressed in tumors. We have previously
Cortactin promotes exosome secretion by controlling branched actin dynamics.
Sinha S, et al.
The Journal of Cell Biology, 214(2), 197-213 (2016)
Cortactin contributes to the tumorigenicity of colorectal cancer by promoting cell proliferation.
Wu H, et al.
Oncology Reports, 36(6), 3497-3503 (2016)
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