SAB4504388
Anti-phospho-eIF2 α (pSer51) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-EIF-2, Anti-EIF-2A, Anti-EIF-2alpha, Anti-EIF2, Anti-EIF2A
产品名称
Anti-phospho-eIF2 α (pSer51) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 36 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer51)
Quality Level
Gene Information
human ... EIF2S1(1965)
Application
Anti-phospho-eIF2 α(pSer51) antibody has been used in western blotting and immunohistochemistry.
Biochem/physiol Actions
EIF2S1 (eukaryotic translation initiation factor 2 subunit α) acts as a modulator in apoptosis signaling pathway . During endoplasmic reticulum stress, eIF2α plays a major role in signaling pathways in the development of tumor .
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
EIF2S1 (eukaryotic translation initiation factor 2 subunit α) is a heterotrimeric protein and a regulatory subunit of eIF2 . eIF2 has three general subunits- α, βand γ . eIF2α is located on human chromosome 14q23 .
Immunogen
The antiserum was produced against synthesized peptide derived from human eIF2 alpha around the phosphorylation site of Ser51.
Immunogen Range: 21-70
Immunogen Range: 21-70
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats
Ko AR, et al.
Neuroscience, 307, 199-214 (2015)
Vapb/Amyotrophic lateral sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic response
Larroquette F, et al.
Human Molecular Genetics, 24(22), 6515-6529 (2015)
Translational regulator eIF2? in tumor
Zheng Q, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 35(7), 6255-6264 (2014)
Isabella R Straub et al.
Human molecular genetics, 30(8), 687-705 (2021-03-23)
Mutations in CHCHD10, coding for a mitochondrial intermembrane space protein, are a rare cause of autosomal dominant amyotrophic lateral sclerosis. Mutation-specific toxic gain of function or haploinsufficiency models have been proposed to explain pathogenicity. To decipher the metabolic dysfunction associated
The Role of the PERK/eIF2?/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress
Rozpedek W, et al.
Current Molecular Medicine, 16(6), 533-544 (2016)
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