SAB4504429
Anti-phospho-Histone H3.1 (pSer10) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-H3.1, Anti-H3/c, Anti-H3C1, Anti-H3C10, Anti-H3C11, Anti-H3C12, Anti-H3C2, Anti-H3C4, Anti-H3C6, Anti-H3C8, Anti-H3FC, Anti-HIST1H3C
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 15 kDa
种属反应性
human, rat, mouse
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer10)
一般描述
Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A). H3.1 is also called as HIST1H3E. It is mainly expressed in the S phase. HIST1H3E is located on human chromosome 6p22.
免疫原
The antiserum was produced against synthesized peptide derived from human Histone H3.1 around the phosphorylation site of Ser10.
Immunogen Range: 1-50
Immunogen Range: 1-50
生化/生理作用
Histone proteins are basic building blocks of chromatin. Mutations in histone H3 results in adult cerebellar high-grade gliomas. It controls protein-protein interactions to induce binding of trans-acting factors that drive chromatin condensation. H3.1 acts as a replication-dependent histone.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Mario A Miranda et al.
Physiological reports, 8(20), e14573-e14573 (2020-10-29)
Maintenance of functional β-cell mass is critical to preventing diabetes, but the physiological mechanisms that cause β-cell populations to thrive or fail in the context of obesity are unknown. High fat-fed SM/J mice spontaneously transition from hyperglycemic-obese to normoglycemic-obese with
A Comprehensive View of the Epigenetic Landscape Part I: DNA Methylation, Passive and Active DNA Demethylation Pathways and Histone Variants.
Sadakierska-Chudy A, et al.
Neurotoxicity Research, 27(1), 84?97-84?97 (2015)
Navrita Mathiah et al.
EMBO reports, 21(11), e50944-e50944 (2020-10-06)
At gastrulation, a subpopulation of epiblast cells constitutes a transient posteriorly located structure called the primitive streak, where cells that undergo epithelial-mesenchymal transition make up the mesoderm and endoderm lineages. Mouse embryo epiblast cells were labelled ubiquitously or in a
Selective methylation of histone H3 variant H3. 1 regulates heterochromatin replication.
Jacob Y, et al.
Science, 343(6176), 1249-1253 (2014)
Evangéline Despin-Guitard et al.
Nature communications, 15(1), 7364-7364 (2024-08-31)
During the epithelial-mesenchymal transition driving mouse embryo gastrulation, cells divide more frequently at the primitive streak, and half of those divisions happen away from the apical pole. These observations suggest that non-apical mitoses might play a role in cell delamination.
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