SAB4504450
Anti-phospho-SAPK/JNK (pTyr185) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-JNK, Anti-JNK-46, Anti-JNK1, Anti-JNK1A2, Anti-JNK21B1/2, Anti-PRKM8, Anti-SAPK1, Anti-SAPK1c
产品名称
Anti-phospho-SAPK/JNK (pTyr185) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 48 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr185)
Quality Level
Gene Information
human ... MAPK10(5602), MAPK8(5599), MAPK9(5601)
Biochem/physiol Actions
Stress-activated protein kinase 2 (SAPK2) participates in proliferation, differentiation, apoptosis, migration, transcriptional regulation and development. It controls the cellular acidic/lysosomal cellular compartment. JNK2 plays an important role in mediating stress-induced apoptosis and modulating gene expression.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
MAPK9 (mitogen-activated protein kinase 9)/JNK2 (C-Jun N-terminal kinase 2)/ stress-activated protein kinase 2 (SAPK2) spans around 58494bp. The JNK2 gene is located on human chromosome 5q35. It has 17 introns.
Immunogen
The antiserum was produced against synthesized peptide derived from human SAPK/JNK around the phosphorylation site of Tyr185.
Immunogen Range: 151-200
Immunogen Range: 151-200
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
JNK2 is activated during ER stress and promotes cell survival
Raciti M, et al.
Cell Death & Disease (2012)
MAPK9 (mitogen-activated protein kinase 9)
Chen F
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2003)
Junhui Liu et al.
Annals of translational medicine, 9(3), 260-260 (2021-03-13)
Kiaa0101, a regulator of cell proliferation, is overexpressed in many malignant tumors. However, its role in promoting invasion of glioma is poorly understood. Here, we investigated the effects of Kiaa0101 on glioma invasion and elucidated the underlying mechanisms of action.
Chin-Feng Hsuan et al.
Molecules (Basel, Switzerland), 25(24) (2020-12-17)
The proliferation and migration of vascular smooth muscle cells (VSMCs) are essential in the pathogenesis of various vascular diseases, such as atherosclerosis and restenosis. Among the mediators of VSMC during atherosclerosis development, platelet-derived growth factor (PDGF)-BB is a potent mitogen
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