SAB4504670
Anti-phospho-FRS2 (pTyr436) antibody produced in rabbit
affinity isolated antibody
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
3
Quality Level
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 57 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr436)
Gene Information
human ... FRS2(10818)
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General description
Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) is an FGF receptor (FGFR)-associated protein. It is a membrane-bound adaptor protein, that is located on human chromosome 12q15.
Immunogen
The antiserum was produced against synthesized peptide derived from human FRS2 around the phosphorylation site of Tyr436.
Immunogen Range: 402-451
Immunogen Range: 402-451
Biochem/physiol Actions
Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) is essential for activation of downstream signaling molecules that are involved in the MAP (mitogen-activated protein kinase) and AKT (protein kinase B) kinase pathways. This protein plays an important role in epidermal growth factor (EGF) signaling. It also plays a major role in cell transformation and resistance to therapy. FRS2 helps to link FGF, nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF) receptors with the Ras/mitogen-activated protein (MAP) kinase signaling cascade.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Hyperactivated FRS2?-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients
Liu J, et al.
Oncogene, 35(14), 1750-1759 (2016)
EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2
Wu Y, et al.
Biological Chemistry, 384(8), 1215-1226 (2003)
Leo Y Luo et al.
Molecular cancer research : MCR, 13(3), 502-509 (2014-11-05)
High-grade serous ovarian cancers (HGSOC) are characterized by widespread recurrent regions of copy-number gain and loss. Here, we interrogated 50 genes that are recurrently amplified in HGSOC and essential for cancer proliferation and survival in ovarian cancer cell lines. FRS2
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