Anti-phospho-VE-Cadherin (pTyr⁷³¹) antibody produced in rabbit

Cadherin 5 (CDH5) is encoded by the gene mapped to long arm of human chromosome 16. The encoded protein is expressed in endothelial cells, but it is absent in normal epithelium.

The antiserum was produced against synthesized peptide derived from human VE-Cadherin around the phosphorylation site of Tyr731.

Immunogen Range: 697-746

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Cadherin 5 (CDH5) plays an essential role in various cellular processes, such as regulation of cell adhesion, cell proliferation, cell survival, cell shape, cell motility, modulation of signaling pathways and transcriptional gene regulation. Cdh5/VE(vascular endothelial)-cadherin is a core component of endothelial adherens junction, which plays a vital role in angiogenic sprouting by enhancing cell migration and cell elongation. CDH5 expressed in glioblastoma multiforme (GBM), facilitates the transdifferentiation of glioblastoma stem-like cells (GSCs) to endothelial cells and to form blood vessels, under hypoxia condition. VE-cadherin induces endothelial cell-cell adhesion at adherens junctions (AJs). CDH5 gene knockout results in loss of cell polarity and modification in vascular lumenal structure. CDH5 inhibits the synthesis of CDH2 (also known as N-cadherin) in the endothelium.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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