产品名称
抗-磷酸-p47 phox（pSer345） 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 44 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer345)
Quality Level
Gene Information
human ... NCF1(653361)
Biochem/physiol Actions
中性粒细胞胞浆因子1（NCF1）在高氧条件下刺激产生活性氧（ROS）。上述过程可被NCF1抑制剂二苯基碘化物（DPI）和罗布麻宁抑制。对该基因的突变会导致一种罕见的先天性免疫缺陷，称为慢性肉芽肿性疾病（CGD）。NCF1基因删除是NADPH氧化酶复合体的重要组成部分，与氧化应激的产生有交，会导致Williams综合征。它还可作用血管硬度的修饰剂。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
Features and Benefits
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General description
中性粒细胞胞质因子1（NCF1），也被称为p47phox基因，大小为15kb，具有11个外显子，定位于人类染色体7q11.23上。该基因可编码一个390个氨基酸的蛋白质，该蛋白质是NADPH氧化酶复合物的一个新型组成部分。
Immunogen
针对从人p47 phox Ser345的磷酸化位点周围衍生的合成肽产生抗血清。
免疫原范围：311-360
免疫原范围：311-360
Physical form
兔IgG，溶于磷酸盐缓冲盐水（不含Mg2+和Ca2+），pH7.4，150mM NaCl，0.02％叠氮化钠和50％甘油中。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
U Francke et al.
American journal of human genetics, 47(3), 483-492 (1990-09-01)
Chronic granulomatous disease (CGD) is a heterogeneous group of inherited disorders of impaired superoxide production in phagocytes. The most common X-linked recessive form involves the CYBB locus in band Xp21.1 that encodes the membrane-bound beta subunit of the cytochrome b558
Beth A Kozel et al.
Hypertension (Dallas, Tex. : 1979), 63(1), 74-79 (2013-10-16)
Williams syndrome is caused by the deletion of 26 to 28 genes, including elastin, on human chromosome 7. Elastin insufficiency leads to the cardiovascular hallmarks of this condition, namely focal stenosis and hypertension. Extrapolation from the Eln(+/-) mouse suggests that
Astghik Hayrapetyan et al.
Biochimica et biophysica acta, 1832(10), 1662-1672 (2013-05-22)
Chronic granulomatous disease (CGD) is a rare congenital disorder in which phagocytes cannot generate superoxide (O2(-)) and other microbicidal oxidants due to mutations in one of the five components of the O2(-)-generating NADPH oxidase complex. The most common autosomal subtype
Lingping Zhang et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 32(1), 59-62 (2016-01-06)
To observe the effects of NADPH oxidase inhibitor diphenylene iodonium (DPI) and apocynin on the generation of reactive oxygen species (ROS) induced by p47phox and the mechanism of p47phox-induced ROS production under hyperoxic conditions. Peripheral blood mononuclear cells (PBMCs) were
Trishan Vaikunthanathan et al.
EBioMedicine, 95, 104778-104778 (2023-09-02)
Dysregulated inflammatory responses and oxidative stress are key pathogenic drivers of chronic inflammatory diseases such as liver cirrhosis (LC). Regulatory T cells (Tregs) are essential to prevent excessive immune activation and maintain tissue homeostasis. While inflammatory cues are well known
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